Advances in data and technology have opened the door to innovative clinical trial designs that are more convenient for patients, can drive faster development, and provide more personalized treatments. These designs embrace approaches like predicting outcomes through simulation models; deploying master protocols that enable the simultaneous investigation of multiple therapies; leveraging digital health technologies and novel endpoints; registry trials; trials embedded in clinical practice that utilize existing data and infrastructure; and many others.  

While innovative trial designs offer transformative potential to accelerate the development of new treatments for patients, knowing how and when to use them is critical. Use CTTI’s comprehensive suite of recommendations and resources to evaluate and deploy these designs, anticipate different logistics, navigate regulatory complexity, and support internal change management.