A new CTTI publication published in the Journal of Clinical and Translational Science highlights the qualitative research findings that informed recommendations to facilitate the integration of clinical trials into clinical practice. By integrating key elements of clinical trials—such as patient identification and data collection—into everyday practice, research efforts can be streamlined to reduce duplication of activities. However, several administrative, cultural, and data-related challenges must be addressed to fully realize these benefits. 

The publication identifies barriers to embedding clinical trials into routine practice, including potential disruptions to workflow, challenges in obtaining buy-in from staff, the need for robust data and research infrastructure, and the necessity for a culture shift to value and support research. 

To address these barriers, recommendations are provided based on in-depth interviews and insights from two expert meetings hosted by CTTI. Key suggestions include ensuring healthcare data sources are research-ready, aligning trial designs with existing clinical workflows, preparing sites for trial integration, and securing support from leaders at regulatory, funding, and health system levels to champion the value of embedding trials in routine practice. 

Integrating trial elements into everyday clinical practice does not have to be an “all or none” approach. Even incorporating a few elements can bring significant benefits. By addressing the identified barriers and following these recommendations, long-term improvements in operational efficiency and patient outcomes can be achieved.