Since CTTI’s inception in 2007, we’ve published 33 peer-reviewed papers in our quest to identify and promote practices that will increase the quality and efficiency of clinical trials. Today, we’d like to highlight our top three most cited publications.*

#1) Rethinking randomized clinical trials for comparative effectiveness research: the need for transformational change
CITED 156 TIMES
Authors: Luce BR, Kramer JM, Goodman SN, Connor JT, Tunis S, Whicher D, Schwartz JS
Journal: Annals of Internal Medicine
Publication Date: August 4, 2009
This article addresses several fundamental limitations of traditional randomized clinical trials for meeting comparative effectiveness research (CER) objectives and offers 3 potentially transformational approaches to enhance their operational efficiency, analytical efficiency, and generalizability for CER.

#2) The Clinicaltrials.gov Results Database – Update and Key Issues
CITED 154 TIMES
Authors: Zarin DA, Tse T, Williams RJ, Califf RM, Ide NC
Journal: The New England Journal of Medicine
Publication Date: March 3, 2011
This publication resulted from CTTI’s State of Clinical Trials project. The authors present an update on relevant policies, summarize the structure and contents of the results database, and show how ClinicalTrials.gov data can be used to gain insight into the state of clinical research.

#3) Characteristics of clinical trials registered in clinicaltrials.gov, 2007-2010
CITED 91 TIMES
Authors: Califf RM, Zarin DA, Kramer JM, Sherman RE, Aberle LH, Tasneem A
Journal: JAMA
Publication Date: May 2, 2012
This publication resulted from CTTI’s State of Clinical Trials project. The authors examine fundamental characteristics of interventional clinical trials registered in the ClinicalTrials.gov database.

To view a complete list of CTTI’s Publications, CLICK HERE.

*Citation data source: web of science (August 3, 2015)