In December 2024, CTTI launched the Collective Strategies to Enhance Proportionate Enrollment project to improve communication, accountability and clarity across clinical trial partner groups. The project focuses on addressing persistent challenges that hinder the enrollment and retention of participants who reflect the populations most affected by the disease under study. 

Through this effort, CTTI aims to foster unified, action-focused collaboration among sponsors, contract research organizations, sites, patient organizations and other key groups involved in clinical research. By strengthening coordination and aligning expectations, the project will help identify practical strategies to improve how trials are planned and executed. 

To inform this work, CTTI is gathering evidence through qualitative methods, including interviews with individuals involved in clinical trial operations, to better understand group-specific needs and challenges. These insights will shape a set of recommendations and tools that clarify roles, outline implementation considerations and support proportionate enrollment across the trial lifecycle. 

Ultimately, this project will support the generation of high-quality, reliable data and the development of medical products that are safe and effective for all populations. These efforts align with CTTI’s Transforming Trials 2030 vision to create a more efficient, patient-centered and representative clinical trial enterprise.