Electronic health record data and real-world data, collected through the routine delivery of health care, are potentially powerful tools for enhancing the quality and efficiency of clinical trials. We can use existing data to plan eligibility criteria, assess trial feasibility and generalizability, and target recruitment efforts to shorten timelines and enhance patient access to research efforts. Appropriately sharing data and methods with all researchers and sponsors can spark collaboration and innovation in clinical trials. In CTTI’s 2030 vision for clinical trials: