CTTI’s Transforming Trials 2030 vision guides our priorities, and we encourage others within the clinical trial enterprise to use the TT2030 vision to evaluate and prioritize their organizational goals and activities. Currently, the TT2030 vision lacks metrics to demonstrate progress toward the vision’s five central goals and the focused objectives within each goal. In order to gauge progress, CTTI is working to select measures that matter and evaluate a current baseline based on the scores of a subset of recent trials. Once a baseline is established, CTTI will set key milestones to monitor, evaluate, and assess progress over time. 

Measuring Clinical Trials Transformation: Developing a Common Framework

As part of this work, CTTI will: 

• Create a framework for measuring progress towards the TT2030 vision, including a parsimonious set of metrics corresponding to each of the five pillars and related domains 
• Determine methods and necessary data collaborations for collecting and reporting on an initial set of TT2030 metrics
• Establish a dashboard to inform metrics fulfillment for the TT2030 Vision  

Transparency for what is meaningful to measure in the clinical trials enterprise with a proposed metrics framework.

CTTI will determine an initial set of feasible metrics for collection by CTTI and other organization using existing data, established surveys, and other methods. To develop a set of relevant metrics, CTTI will utilize a variety of iterative strategies, including interviews with key stakeholders on their experiences with each pillar and ideas for related metrics, expert surveys on draft measures for each pillar, and an online public forum on the measurement framework. CTTI will refine the selected metrics by integrating public comment, expert input, and project team feedback and discussions. CTTI will perform a case study using the framework of metrics to measure progress towards the TT2030 vision by collecting and reporting an initial set of metrics using recent clinical trials.

The Measuring Trials Transformation project is expected to yield the following: 

• A parsimonious set of meaningful metrics that monitor, evaluate, and analyze progress towards the TT2030 vision 
• Publications on metrics approach, framework, and case studies for use of metrics framework
• A dashboard of metrics to be measured and tracked by CTTI and linked metrics being measured by other organizations 

Organization affiliations are listed as active affiliations during the project.

*Indicates former project manager, team leader, or team member.